HPV

 

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Genomics, Proteomics and Vaccines

Genomics, Proteomics and Vaccines
The field of vaccine development is one of the first to benefit from the new technologies of genomics, proteomics and bioinformatics. The complete genome sequences of many bacteria are available and comparisons of pathogenic strains with non-pathogenic relatives are becoming common. Vaccines can now be targeted towards specific gene products that traditional vaccine research failed to discover. This book describes the current status of this field and summarizes the various strategies that are delivering results. The introductory section provides an overview of vaccine research and looks at how genomics can complement traditional approaches. The second section focuses on advanced technologies, such as genome sequence analysis, microarrays, proteomics and high-throughput cloning. The third section constitutes the unique part of this book, with six chapters that describe the application of genomic and proteomic techniques in the search for new antibacterial vaccines. The target pathogens include meningococcus B, streptococci, chlamydia and "Pseudomonas. Infectious diseases are once again threatening the health of human populations, even in countries where they were thought to have been controlled. With the spread of antibiotic resistance, the concept of prevention rather than cure becomes ever more important. The new genomic approaches described in this book will help to accelerate vaccine development and benefit the health of millions of people worldwide. This book should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions.



The Politics of International Health: The Children's Vaccine Initiative and the Struggle to Develop Vaccines for the Third World by William Muraskin,
The Politics of International Health: The Children's Vaccine Initiative and the Struggle to Develop Vaccines for the Third World by William Muraskin,
Tracing the history of the Children's Vaccine Initiative (CVI), this book examines its successes and failures in promoting the development of both new and improved vaccines for the Third World. The CVI has achieved many successes, including making vaccination a top international public sector priority. Most of its failures have stemmed from the often bitter competition between the fledgling Initiative and the notoriously turf-conscious and inefficient World Health Organization (WHO), over their respective roles in championing vaccines. Vaccines are the most inexpensive means of improving the health and lowering the mortality of people in the Third World, where infectious diseases kill millions of children every year. As a result of the biotechnology revolution, it is possible that a whole array of new vaccines can be created for diseases which are not yet preventable. What has stood in the way of this major medical breakthrough has been that vaccine "product development" has been in the hands of commercial companies, whose activities are dominated by the need for maximizing profit, which the Third World poor cannot generate.



HPV vaccine - Human papillomavirus vaccine research focuses on the prevention of cervical cancer, particularly in developing countries, where regular cervical examinations are uncommon. HPV infection is the overwhelming cause of cervical cancer growth in women.

Biodefense and Pandemic Vaccine and Drug Development Act of 2005 - The Biodefense and Pandemic Vaccine and Drug Development Act of 2005 (S. 1873), nicknamed "Bioshield Two" and sponsored by Senator Richard Burr (R-North Carolina), aims to shortcut safety testing for new vaccines and drugs in case of a pandemic, and to protect vaccine makers and the pharmaceutical industry from legal liability for vaccine injuries.

FluMist - FluMist is the product name of a nasal spray vaccine against the flu virus. It is the new type of flu vaccine that is given as a nasal spray.

Jonas Salk - Jonas Edward Salk (October 28, 1914 – June 23, 1995) was an American physician, best known as the inventor of the first polio vaccine (the eponymous Salk vaccine). He was born gffgin New York City to a Russian-Jewish immigrant family and died in La Jolla, California.



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